Hedgehog Pathway Inhibition
نویسندگان
چکیده
The hedgehog (Hh) signaling pathway is aberrantly activated in a majority of basal cell carcinomas (BCC). Vismodegib and sonidegib are targeted inhibitors of Smoothened (SMO). Both drugs are approved for use in locally advanced BCC (laBCC), with vismodegib also approved for metastatic BCC (mBCC).
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عنوان ژورنال:
- Cell
دوره 164 شماره
صفحات -
تاریخ انتشار 2016